手前味噌ながら、2012年に発表した自分の論文を紹介します。

骨粗鬆症骨折患者と、骨折のない患者の筋肉量を初めて比較しました。また、日本人大腿骨頸部骨折患者におけるサルコペニア有病率を検討した初めての報告です。骨折発生のメカニズムにおいてサルコペニアが重要な役割を果たしており、サルコペニアの治療が骨折予防につながる可能性がある。

Hida T, et al.　High prevalence of sarcopenia and reduced leg muscle mass in Japanese patients immediately after a hip fracture.　Geriatr Gerontol Int. 2012 Jul 23. doi: 10.1111/j.[Epub ahead of print])

イタリア人頚部骨折患者の高いSarcopenia有病率(58%)を報告。骨粗鬆症と筋量低下が関連していた。測定時期が受傷後21日と遅く、臥床、安静、手術による筋量低下の影響は否定できない。   Di Monaco M, et al. Prevalence of sarcopenia and its association with osteoporosis in 313 older

women following a hip fracture. Arch Gerontol Geriatr. 2011 Jan-Feb;52(1):71-4. Epub 2010 Mar 5.

要約
Changes in body composition, including a decrease in muscle and bone mass,
accompany aging. Our aim was to assess the prevalence of sarcopenia and its
association with osteoporosis in hip-fracture women. We performed a
Dual-Energy X-Ray Absorptiometry (DXA) scan in 313 of 340 women, 20.9 ± 6.5
(mean ± S.D.) days after hip-fracture occurrence. To adjust appendicular
lean mass for body size we divided it by height squared in each woman. A
total of 180 of the 313 women (58%) were sarcopenic, whereas 230 (74%) were
osteoporotic. After adjustment for age and interval between fracture and DXA
scan we found a significant association between sarcopenia and osteoporosis
(p=0.026). For a sarcopenic woman the adjusted odds ratio (OR) for
osteoporosis was 1.80 (95%CI=1.07-3.02). Our data shows the high prevalence
of sarcopenia and its significant association with osteoporosis in a large
sample of hip-fracture women. Data supports a research approach on
preventive and treatment strategies for osteoporosis and sarcopenia
targeting both bone and muscle tissue. Furthermore, data should be
considered when the economic burden of sarcopenia is estimated, given the
high proportion of sarcopenic women with bone fragility.

2011-03-30