昨年末にサルコペニアのレビュー論文を上梓しました。
サルコペニアと骨折の関連はもとより、サルコペニアの歴史、定義、病態、分子生物学的機序、治療法に関する最新の知見を網羅的に俯瞰しており、サルコペニアに関わる研究者にとって有益な文献になったと自負しております。初めてのレビュー論文執筆でしたが、サルコペニアの知識の整理をする良い機会になりました。
Aging and Disease という米国のNeurologyを中心とした老年学の基礎と臨床の雑誌です。現在のところE-pubのみですが、もうしばらくしたらPubMedに収載されるかと思います。
Aging and Disease Volume 5 (2), xxx-xxx; 2013, 26 November [Epub ahead of print
Review
Managing Sarcopenia and Its Related-Fractures to Improve Quality of Life in Geriatric Populations
Tetsuro Hida, et al.
ABSTRACT: Sarcopenia, an aging-induced generalized decrease in muscle mass, strength, and function, is known to affect elderly individuals by decreasing mobile function and increasing frailty and imbalance that lead to falls and fragile fractures. Sarcopenia is a known risk factor for osteoporotic fractures, infections, and early death in some specific situations. The number of patients with sarcopenia is estimated to increase to 500 million people in the year 2050. Sarcopenia is believed to be caused by multiple factors such as disuse, malnutrition, age-related cellular changes, apoptosis, and genetic predisposition; however, this remains to be determined. Various methods have been developed, but no safe or effective treatment has been found to date. This paper is a review on the association between sarcopenia and its related-fractures and their diagnoses and management methods to prevent fractures.
2014-06-03